D-3Science and Technology and other Research and Development

DoW Breast Cancer, Breakthrough Award Levels 1 and 2

Agency: Department of Defense
Run by: Danielle Reckley Grantor
Target applicants: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
Application period: 2026-09-03 ~ 2026-11-18
Contact: Danielle Reckley Grantor 301-619-1139

Open in EDIT and start the application View on Grants.gov Application site

Source: Grants.gov

How to apply

Register your organization on SAM.gov to get a UEI (Unique Entity ID). It can take up to 10 business days to become active, and it must be renewed every year. SAM.gov
Create a Grants.gov account and add an applicant profile with your UEI. The E-Business Point of Contact named in SAM.gov gives the person who submits the AOR role. Grants.gov
On the opportunity page, select Apply to create a Workspace. Complete the SF-424 and the other required forms in Workspace. Opportunity page
Attach the narrative documents the NOFO asks for (such as the Project Narrative, Project Abstract and Budget Justification) in Workspace. EDIT can draft them from your materials. Workspace
Submit from Workspace, then check the status with your Grants.gov tracking number. Track my application

Overview

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Breakthrough Award mechanism supports promising research with high potential to lead to or make breakthroughs in breast cancer. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception. Applications must address the challenge in a way that can lead to a breakthrough and have major impact. The FY26 Breakthrough Award mechanism contains four different funding levels designed to support major (but not all) stages of research that will lead to clinical application. Each level specifies a distinct research scope. This program announcement discusses the Breakthrough Award Levels 1 and 2. Distinctive Features: * This funding mechanism allows for applications submitted under Funding Level 1 or Funding Level 2. Funding Level 2 also includes a Population Science Studies option. With compelling justification, population science studies may request higher levels of funding and an additional year in the period of performance. * This funding mechanism allows for a single Principal Investigator (PI), or two partnering PIs referred to as the Initiating PI and the Partnering PI. For the Partnering PI Option (PPIO), only the Initiating PI will submit a pre-application, but both PIs will need to submit at the full application stage. Be advised, failure to submit all associated (Initiating and Partnering PI) applications by the deadline may result in administrative withdrawal. Estimated total funding: $10,600,000 Expected awards: 6 Opportunity number: HT942526BCRPBTA122